【English】NMN/NAD⁺ Therapy

What Are NMN and NAD⁺?

NAD⁺ (Nicotinamide Adenine Dinucleotide) is a vital coenzyme found in all living cells. It plays a central role in numerous metabolic processes, DNA repair, mitochondrial function, and cellular energy production. In the body, NAD⁺ is synthesized from NMN (Nicotinamide Mononucleotide), a naturally occurring compound.
As we age, the level of NAD⁺ in our cells gradually declines. This reduction is associated with decreased cellular function and various age-related conditions. By supplementing NAD⁺—either directly or through NMN administration—it may be possible to:

• Improve energy levels and reduce fatigue
• Enhance memory and cognitive function
• Strengthen immune resilience
• Support healthy aging and skin vitality

NAD⁺ is also believed to activate sirtuin genes, which are linked to longevity and cellular repair. Maintaining adequate NAD⁺ levels may contribute to mitochondrial rejuvenation and enhanced stem cell performance.
In addition, NAD⁺ is deeply involved in regulating the body’s circadian rhythm—the internal clock that governs sleep-wake cycles, hormonal balance, metabolism, energy levels, and body temperature.

At Kita-Aoyama D.CLINIC, NMN/NAD⁺ intravenous therapy is offered as part of a science-based approach to age management. This therapy aims to activate sirtuins and support overall biological functions—ranging from skin health and physical endurance to cognitive clarity and recovery from fatigue.
It may be particularly beneficial for individuals who have become more aware of age-related changes, struggle with memory lapses or mental fog, experience persistent fatigue or a loss of vitality, or are concerned about visible signs of skin aging and declining physical performance. Our goal is to help you maintain a more youthful, resilient, and energetic condition, regardless of chronological age.

Enhancing Treatment Efficacy:
Combining IV Therapy with Oral Supplementation

NMN, the precursor to NAD⁺, is naturally found in various foods such as edamame, broccoli, avocados, and certain fruits and seeds. However, obtaining a sufficient amount through diet alone is extremely difficult—for example, consuming 100 mg of NMN would require approximately 40 kilograms of broccoli. To ensure more effective and sustained increases in NAD⁺ levels, we offer the following treatment options:

1. Intravenous (IV) Therapy
2. Combination Therapy (IV + Supplementation)
3. Supplementation Only

At Kita-Aoyama D.CLINIC, we recommend a comprehensive approach that includes regular NAD⁺ or NMN infusions at our clinic, combined with daily NMN supplements at home. This integrated protocol may lead to more consistent and long-lasting therapeutic effects.

Potential Benefits of NMN/NAD⁺ Therapy

• Activation of sirtuin genes, associated with longevity and cellular repair
• Improved skin tone, texture, and appearance—reducing dullness, fine lines, and pigmentation
• Enhanced recovery from fatigue and increased physical resilience
• Better sleep quality and more stable sleep-wake cycles
• Boosted metabolism, potentially supporting healthy weight management
• Improved cognitive function, including clarity of thought, focus, and memory

These outcomes may vary depending on individual health status, age, and lifestyle factors. Our medical team will help tailor the therapy to best align with each patient’s goals and condition.

Who May Benefit from NMN/NAD⁺ Therapy

• This therapy may be suitable for individuals who:
• Have recently become more aware of age-related changes
• Experience noticeable memory lapses or mental fatigue
• Struggle with persistent tiredness or low energy levels
• Feel a general decline in overall health or vitality
• Are concerned about visible signs of skin aging

If you identify with any of the above, NMN/NAD⁺ therapy may help support your physical and cognitive well-being as part of a comprehensive age-management approach.

Treatment Fees

NMN IV Therapy / NAD⁺ IV Therapy / NMN Supplementation

Aimed at supporting the recovery of age-related decline in physical functions such as reduced metabolism, cognitive decline, and prolonged fatigue.

Notes:
Mild bruising or discomfort at the injection site may occur.
These treatments are not covered by public insurance and are provided as elective (self-funded) medical care.
Results may vary depending on the individual.

Frequently Asked Questions

• Will I feel the effects after just one treatment?

  Some individuals report feeling subtle improvements—such as reduced fatigue and enhanced stamina—even after a single infusion. However, for more sustained and noticeable results, we recommend combining IV therapy with daily supplementation, and continuing IV sessions once or twice per month as part of a regular regimen.

• What is the difference between NMN and NAD⁺ IV therapy, and how should I choose?

  In anti-aging and wellness medicine, NMN (Nicotinamide Mononucleotide) infusions are more commonly used. NMN is a precursor to NAD⁺ (Nicotinamide Adenine Dinucleotide) and is converted naturally within the body, helping to increase NAD⁺ levels in a physiologically harmonious way.
  NAD⁺ IV therapy, in contrast, delivers NAD⁺ directly into the bloodstream. While this method offers a stronger pharmacological effect, NAD⁺ is less efficiently absorbed at the cellular level and may be more likely to cause mild side effects in some individuals.
  Nonetheless, NAD⁺ infusions have been used therapeutically for conditions such as schizophrenia and autism spectrum disorders, and when administered under medical supervision, they may provide significant benefits. In recent years, their application has expanded into age-related care and longevity medicine.
  For patients who do not experience sufficient benefits from NMN therapy alone, NAD⁺ IV therapy may be considered as an alternative option, based on individual health status and treatment response.